Source: Press Release 10/5/2011

Mannatech Announces Findings of Ambrotose Study

COPPELL, Texas, Oct 04, 2011 -- Mannatech, Incorporated, the leading innovator and provider of nutritional supplements and skin care products based on Real Food Technology(R) solutions, announced findings today from a randomized, double-blind, placebo-controlled trial involving more than 100 healthy adults and its Ambrotose(R) complex powder.

The study compared the adults who consumed Ambrotose to those who consumed a placebo, and individuals who consumed the complex powder reported numerous health and well-being benefits following 12 weeks of intake. The study, conducted by Dr. Talitha Best and colleagues in Australia, was published in the peer-reviewed journal Applied Research in Quality of Life.

"Dr. Best has been committed to investigating the impact of plant saccharides, including Mannatech's Ambrotose complex, on brain function for more than six years," said Dr. Robert Sinnott, co-CEO and chief science officer of Mannatech. "In this blinded study, healthy adults taking Ambrotose complex powder perceived numerous quality-of-life benefits, including some that have been confirmed by formal cognitive testing (1)+,(2)+*. Because our preclinical research suggests the product also provides gastrointestinal benefits, we were pleased that gastrointestinal effects were among the perceived benefits reported by individuals who consumed Ambrotose complex."

The Australian government recently awarded Dr. Best a 12-month Researchers in Business (RiB) grant to help develop research on Mannatech's glyconutritional products and to promote Australian research innovation. The $10 million RiB program is part of Enterprise Connect, an initiative within the Australian government's Department of Innovation, Industry, Science and Research. The program is designed to accelerate industry innovation and competitiveness by connecting university and public agency researchers with businesses that wish to develop new ideas with commercial potential.

Dr. Best, who conducted the study with Associate Professor Eva Kemps, Flinders University, and Dr. Janet Bryan, University of South Australia (UniSA), is a post-doctoral research fellow at the Nutritional Physiology Research Centre, UNiSA, and the Brain Sciences Institute, Swinburne University of Technology.

+Mannatech provided the Ambrotose supplement and placebo used in this study.

+Mannatech provided partial funding and provided the Ambrotose supplement and placebo used in this study.

Reference List 1. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Dev Neuropsych 2010;35:66-80.

2. Best T, Howe P, Bryan J, Buckley J, Scholey A. Plant polysaccharides, memory and cognition in middle-aged adults. Presented at the 38th Australasian Experimental Psychology Conference in Aukland, New Zealand, April 28-30, 2011.

* These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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